COEH faculty member Martyn Smith and COEH faculty affiliate Luoping Zhang from the UC Berkeley School of Public Health published an up-to-date review on “Functional genomic screening approaches in mechanistic toxicology and potential future applications of CRISPR-Cas9” in Mutation Research Review ahead of print on January 25, 2015. The CRISPR-Cas9 technology, a novel genomic editing tool, can be applied to test toxicities of environmental chemicals.
“It has been used to identify genes involved in the response to chemical and microbial toxicants in several human cell types and could readily be extended to the systematic screening of large numbers of environmental chemicals,” the study reports. In the future, the innovative technology offers the potential to tailor medical treatments to match an individual’s genetic makeup.
In collaboration with scientists at the National Cancer Institute and in China, Smith, Zhang, and COEH faculty Stephen Rappaport and Alan Hubbard published their influential work on formaldehyde toxicity in the stem/progenitor cells of Chinese workers in the January 2015 issue of the journal, Carcinogenesis.
Read the study in Mutation Research Review.
Read the study in Carcinogenesis.
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