Associate Professor of Medicine
School of Medicine
Division of Occupational and Environmental Medicine
University of California
San Francisco, CA 94143-0854
415-206-3513 Fax: 415-206-4123
Current Research Interests
Role of apoptosis in protection from asbestos-induced malignancy
Mechanisms of asbestos-induced DNA damage and apoptosis
Biological modification of asbestos
Mesothelial cell biology
Narasimhan SR, Yang L, Gerwin BI, Broaddus VC. 1998. Resistance of pleural mesothelioma cell lines to apoptosis: relation to expression of Bcl-2 and Bax. Am J Physiol 275(Lung Cell Mol Physiol 19): L165-71.
Broaddus VC, Yang L, Scavo LM, Ernst JD, Boylan AM. 1996. Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species. J Clin Invest 98:2050-59.
Boylan AM, Sanan DA, Sheppard D, Broaddus VC. 1995. Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin avb5. J Clin Invest 96:1987-2001.
Broaddus VC, Hoeffel JM, Boylan AM, Sadick M, Chuntharapai A, Kim KJ, Hébert CA. 1994. Neutralization of interleukin-8 inhibits neutrophil influx in a rabbit model of endotoxin-induced pleurisy. J Immunol 152:2960-67.
Boylan AM, Rüegg C, Hoeffel J, Kim KJ, Hébert CA, Pytela R, Sheppard D, Goldstein IM, Broaddus VC. 1992. Evidence of a role for mesothelial cell-derived interleukin-8 in the pathogenesis of asbestos-induced pleurisy in rabbits. J Clin Invest 89:1257-67.
Clinical Investigator Award, NHLBI, 1987
Distinction in Teaching Award, Academic Senate, UCSF, 1991
Public and University Service
Chief, Pulmonary and Critical Care Medicine
Chair, Long Range Planning Committee of Respiratory Cell and Molecular Biology Assembly, American Thoracic Society