Courtney Broaddus

Courtney Broaddus, MD

Associate Professor of Medicine
School of Medicine
Division of Occupational and Environmental Medicine
University of California
San Francisco, CA 94143-0854
415-206-3513 Fax: 415-206-4123
Current Research Interests
• Role of apoptosis in protection from asbestos-induced malignancy
• Mechanisms of asbestos-induced DNA damage and apoptosis
• Biological modification of asbestos
• Mesothelial cell biology
Key Publications
• Narasimhan SR, Yang L, Gerwin BI, Broaddus VC. 1998. Resistance of pleural mesothelioma cell lines to apoptosis: relation to expression of Bcl-2 and Bax. Am J Physiol 275(Lung Cell Mol Physiol 19): L165-71.
• Broaddus VC, Yang L, Scavo LM, Ernst JD, Boylan AM. 1996. Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species. J Clin Invest 98:2050-59.
• Boylan AM, Sanan DA, Sheppard D, Broaddus VC. 1995. Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin avb5. J Clin Invest 96:1987-2001.
• Broaddus VC, Hoeffel JM, Boylan AM, Sadick M, Chuntharapai A, Kim KJ, Hébert CA. 1994. Neutralization of interleukin-8 inhibits neutrophil influx in a rabbit model of endotoxin-induced pleurisy. J Immunol 152:2960-67.
• Boylan AM, Rüegg C, Hoeffel J, Kim KJ, Hébert CA, Pytela R, Sheppard D, Goldstein IM, Broaddus VC. 1992. Evidence of a role for mesothelial cell-derived interleukin-8 in the pathogenesis of asbestos-induced pleurisy in rabbits. J Clin Invest 89:1257-67.
• Clinical Investigator Award, NHLBI, 1987
• Distinction in Teaching Award, Academic Senate, UCSF, 1991
Public and University Service
• Chief, Pulmonary and Critical Care Medicine
• Chair, Long Range Planning Committee of Respiratory Cell and Molecular Biology Assembly, American Thoracic Society