University of California
David J. Erle, MD

David J. Erle, MD

Professor of Medicine
School of Medicine
Division of Occupational and Environmental Medicine
University of California, San Francisco
Box 2922
San Francisco, CA 94143-0854
415-514-4370 Fax: 415-514-4278
Creative Achievements
• Analyzed the structure and function of proteins involved in immune and inflammatory responses
• Identified a critical mechanism that contributes to asthma pathogenesis
Current Research Interests
• Asthma (mouse models)
• Pulmonary immunology
• Cell adhesion molecules
• Chemokines and other cytokines
• Functional genomics
Key Publications
• Abitorabi MA, Pachynski RP, Ferrando RE, Tidswell M, Erle DJ. Presentation of Integrins on Leukocyte Microvilli: A Role for the Extracellular Domain in Determining Membrane Localization. J Cell Biol 139:563-71, 1997.
• Pachnyski RK, Wu SW, Gunn MD, Erle DJ. Secondary Lymphoid Tissue Chemokine (SLC) Stimulates Integrin alpha 4 beta 7-mediated Adhesion of Lymphocytes to Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1) under Flow. J Immunol 161:952-56, 1998.
• Venkayya R, Lam M, Rodriguez M, Grünig G, Corry DB, Erle DJ. The Th2 Lymphocyte Products IL-4 and IL-13 Rapidly Induce Airway Hyperresponsiveness through Direct Effects on Resident Airway Cells. Am J Respir Cell Mol Biol 26:202-8, 2002.
• Kuperman D, Huang X, Koth LL, Chang GH, Zhu Z, Elias JA, Sheppard D, Erle DJ. Direct Effects of Interleukin-13 on Epithelial Cells Cause Airway Hyperreactivity and Mucus Overproduction, Two Central Features of Asthma. Nature Med 8:885-0, 2002.
• Barczak A, Rodriguez MW, Hanspers K, Koth LL, Tai YC, Bolstad BM, Speed TP, Erle DJ. Spotted Long Oligonucleotide Arrays for Human Gene Expression Analysis. Genome Res 13: 1775-85, 2003.
• Clinical Teaching (Pulmonary Disease, Critical Care at UCSF)
• Biomedical Sciences (UCSF)