Bruce Hammock, PhD

Professor
Department of Entemology and Nematology
University of California
Davis, CA 95618
530-752-7519
bdhammock@ucdavis.edu
Hammock Labaratory of Pesticide Biotechnology

Research Interests
• Biochemistry and physiology of endocrine regulation in insects
• Development of recombinant viral pesticides
• Disruption of chemical mediation by chemical means and biotechnology
• Comparative pesticide metabolism in insects and mammals
• Metabolism of epoxidized xenobiotics
• Immunochemical methodology for detection of xenobiotics.

Key Publications

Lee, K.S.S., J.Y. Liu, K. Wagner, S. Pakhomova, H. Dong, C. Morissuea, J. Yang, P. Wang, A. Ulu, C. Mate, L. Nguyen, S.H. Hwang, M. Edin, A. Mara, H. Wulff, M. Newcomer, D. Zeldin and B. D. Hammock. 2014 Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J Med Chem. 57(16):7016-30. PMCID: PMC4148150

Zhang, G.D., D. Panigraphy, L. Mahakian, J. Yang, J.Y. Liu, K.S.S. Lee, H.I. Wettersten, A. Ulu, X. Hu, S. Tam, S.H. Hwang, E. Ingham, R.H. Weiss, K.W. Ferrara and B.D. Hammock. 2013. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth and metastasis. Proc Natl Acad Sci USA. 110(16):6530-35. PMCID: PMC3631682.

Bever, C.R.S, Z. Majkova, R. Radhakrishnan, I. Suni, M. McCoy, Y. Wang, J. Dechant, S.J. Gee and B.D. Hammock. 2014. Development and utilization of camelid VHH antibodies from alpaca for 2,2,4,4 tetrabrominated diphenyl ether detection. Anal Chem. 86(15):7875-82. PMCID: PMC4144723.

Morisseau C, Hammock BD (2013) Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health. Annu Rev Pharmacol Toxicol. 53:37–58. PMCID: PMC3578707.

Han, J.H., H.J. Kim, S. Lakshmana, S.J. Gee, B.D. Hammock and I.M. Kennedy. 2013. Photonic crystal lab-on-a-chip for detecting Staphylococcal enterotoxin B at low attomolar concentration. Anal Chem. 85(6):3104-09. PMCID: PMC3608201.

Lee, K.S.S., C. Morisseau, J. Yang, P. Wang, S.H. Hwang and B.D. Hammock. 2013. Förster resonance energy transfer (FRET) competitive displacement assay for human soluble epoxide hydrolase. Anal Biochem. 434(2):259-268. PMCID:

Zhang, G.D., D. Panigraphy, L. Mahakian, J. Yang, J.Y. Liu, K.S.S. Lee, H.I. Wettersten, A. Ulu, X. Hu, S. Tam, S.H. Hwang, E. Ingham, R.H. Weiss, K.W. Ferrara and B.D. Hammock. 2013. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth and metastasis. Proc Natl Acad Sci USA. 110(16):6530-35. PMCID: PMC3631682.

Shen, H.C. and B.D. Hammock. 2012. Discovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indications. J Med Chem. 55(5):1789–1808. PMCID: PMC3420824.

Schmelzer, K.R., L. Kubala, J.W. Newman, I.-H. Kim, J.P. Eiserich and B.D. Hammock. 2005. Soluble epoxide hydrolase is a therapeutic target for acute inflammation.  Proc Natl Acad Sci USA. 102(28):9772-9777. PMCID: PMC1168955.

Imig, J.D., X. Zhao, J.H. Capdevila, C. Morisseau and B.D. Hammock. 2002. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension. Hypertension. 39(2):690-694.

Morisseau, C., M.H. Goodrow, D. Dowdy, J. Zheng, J.F. Greene, J.R. Sanborn, and B.D. Hammock. 1999. Potent urea and carbamate inhibitors of soluble epoxide hydrolases.  Proc Natl Acad Sci USA. 96(16):8849-8854.

Borhan, B., A.D. Jones, F. Pinot, D.F. Grant, M.J. Kurth and B.D. Hammock. 1995. Mechanism of soluble epoxide hydrolase: Formation of an a-hydroxy ester-enzyme intermediate through Asp-333.  J. Biol Chem.  270(45):26923-26930.

Abdel-Aal, Y.A.I. and B.D. Hammock. 1986. Transition state analogs as ligands for affinity purification of juvenile hormone esterase. Science. 233:1073-1076.

Ota, K. and B.D. Hammock. 1980. Cytosolic and microsomal epoxide hydrolases: differential properties in mammalian liver. Science. 207:1479-1481.

Wing, K.D., B.D. Hammock and D.A. Wustner. 1978. Development of an S-bioallethrin specificantibody. J Agric Food Chem. 26(6):1328-1333.

Honors and Awards
Member National Academy of Sciences
National Academy of Investors
Alexander von Humboldt Award in International Agriculture
Brodie Award in Xenobiotic Metabolism

Courses
ETO 214 Mechanisms of Toxic Action