Professor of Medicine
Director, Lung Biology Center
School of Medicine
Chief, Division of Pulmonary, Critical Care, Allergy and Sleep
University of California
San Francisco, CA 94143-0844
UCSF Pulmonary Division
Discovered extreme sensitivity of people with asthma to sulfur dioxide pollution.
Identified crucial role of extracellular matrix receptors in lung inflammation and fibrosis.
Developed novel drugs targeting integrins in development for treatment of pulmonary fibrosis, acute lung injury, asthma and immunotherapy of solid tumors
Current Research Interests
Characterizing in vivo functions of
Developing new approaches to treat asthma and tissue fibrosis
Characterization of fibroblast
• Munger JS, Huang XZ , Kawakatsu H , Griffiths MJD, Dalton SL, Wu JF, Pittet JF, Kaminiski N, Garat C, Matthay MA, Rifkin DB, Sheppard D. 1999. The integrin avß6 binds and activates latent TGFb1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 96:319-28.
• Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, Dolganov G, Glick, A, Sheppard D.Loss of integrin v6-mediated TGF activation causes Mmp12-dependent emphysema. Nature2003 422:169-173.
Jenkins RG, Su X, Su G, Scotton, CJ, Camerer E, Laurent GJ, Davis JE, Chambers RC, MatthayMA, Sheppard D. Ligation of the protease-activated receptor-1 induces avB6 integrin-dependentTGF activation and promotes acute lung injury. J Clin Invest 2006 116:1606-14.
Chen C, Huang X, Atakilit A, Zhu Q-S, Corey SJ, Sheppard D. The integrin a9B1 contributes togranulopoiesis by enhancing granulocyte colony stimulating factor receptor signaling. Immunity2006 25:895-906.
Travis MA, Reizis B, Melton AC Masteller E, Tang Q, Proctor J, Wang Y, Bernstein X, Huang X,Riechardt L, Bluestone J, Sheppard D. Loss of integrin avB8 on dendritic cells causesautoimmunity and colitis in mice. Nature 2007 449:361-365.
Atabai K, Jame S, Kuo A, Lam M, Dehart G, Xia DD, Azhar N, Werb Z, Sheppard D. Mfge8-mediated collagen endocytosis limits the severity of fibrotic disease. J Clin Invest 2009 219:3713-22.
Kudo M, Melton AC, Chen C, Engler M, Huang KE, Ren X, Wang Y, Bernstein X, Li J, AtabaiK, Huang X, Sheppard D. IL-17A produced by T cells drives airway smooth musclecontraction. Nature Medicine 2012 18:547-554. PMID:22388091
Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, RuminskiPG, Griggs DW, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. Selective vintegrin deletion identifies a core, targetable molecular pathway that regulates fibrosis across solidorgans. Nature Medicine 2013 19:1617-1624 NIHMS495176, PMC3855865.
Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D. The avB1 integrinplays a critical in vivo role in tissue fibrosis. Science Translational Medicine 2015 7:288-294. .
Active member of BMS, Tetrad and PSPG graduate
Public and University Service
Director, Lung Biology Center
Chief, Division of Pulmonary, Critical Care, Allergy and Sleep, Department of Medicine,