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New Concepts in Toxicology & Tools to Use Now

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This workshop seminar will provide an overview of tools and approaches for chemical assessment that are currently being used, and how future approaches may be used to make regulatory decisions, including setting safe levels of exposure. In the 2nd hour, participants will gain hands-on experience with the OECD QSAR Toolbox and the Adverse Outcome Pathway Wiki.

Traditionally, toxicologists and occupational and environmental health professionals have relied upon in vivo animal tests to assess the potential hazards of new and existing chemicals. The recognition of a number of critical limitations inherent in these tests has led to calls for replacing in vivo tests with newer approaches that in many cases could be more human-relevant, faster, less expensive, and more comprehensive than in vivo methods. There have also been incredible advances in computational ability and biotechnology such that our ability to use human cell and tissue models and computational predictive approaches to make regulatory decisions is fast becoming a reality.

US regulatory agencies have stated intentions to replace specific animal tests with new methods and approaches. Internationally, the Organization for Economic Cooperation and Development has collaborated with regulatory agencies and stakeholders throughout the world to create publicly-available tools and knowledge collection frameworks, such as the OECD QSAR Toolbox and the Adverse Outcome Pathway Wiki, to advance a human-relevant chemical testing paradigm.

 

For complete information and registration, visit http://www.coehce.org.

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